The Best Time to Take CoQ10 for Optimal Health Benefits

by Michael Gonzales | October 5, 2023

The Best Time to Take CoQ10 for Optimal Health Benefits

Are you looking to optimize your health and well-being? Coenzyme Q10 (CoQ10) might just be the missing piece in your wellness puzzle. This powerful antioxidant plays a crucial role in energy production and offers a  myriad of health benefits. But when is the best time to take CoQ10, and how much should you take? In this blog post, we’ll dive into everything you need to know about CoQ10 supplementation from understanding to when should I take CoQ10 benefits, to choosing the right form for your individual needs. Let’s get started on your journey to optimal health!

Short Summary

  • CoQ10 is a naturally occurring antioxidant found in the human body with numerous health benefits.
  • Consult a healthcare professional to determine optimal dosage, timing and form of CoQ10 supplementation for individual needs.
  • Dietary sources such as oily fish, organ meats, whole grains and vegetables can also help maintain adequate levels of CoQ10.

Understanding CoQ10

Understanding CoQ10
CoQ10 is a fat-soluble antioxidant which is naturally present in every human cell. It is most concentrated inside the mitochondria. This vital compound plays a dual role in our bodies, enhancing energy production and functioning as a potent antioxidant. CoQ10 safeguards cells from potential harm, offering many health benefits and supporting overall well-being.

Research suggests that our bodies’ natural CoQ10 production decreases with age, making supplementation beneficial for maintaining optimal levels. Decreased CoQ10 production starts in the heart from age 26 and in the skin from age 30. As a result, dietary intake alone may not be sufficient to maintain optimal CoQ10 levels as we age.

A CoQ10 blood test can help confirm the correct form and dosage for your specific needs.

The role of CoQ10 in energy production

CoQ10 plays a pivotal role in generating energy within the mitochondria of cells, typically known as the cell’s powerhouse. CoQ10 stimulates mitochondria, enhancing the production of adenosine triphosphate (ATP) energy, which contributes to the overall health brain function and vitality of cells.

In addition to its role in energy production, coenzyme q10 also serves as an antioxidant in mitochondrial membranes, protecting them from damage caused by harmful free radicals and supporting mitochondrial function. This dual function makes CoQ10 a vital component in maintaining our bodies’ metabolic processes and overall well-being throughout the aging process, while also supporting mitochondrial function.

Health benefits of CoQ10 supplementation

Incorporating CoQ10 into your daily supplement regimen can bolster different areas of your health. For instance, it may improve heart health by reducing the risk of cardiovascular-related complications and heart disease, as well as managing high blood pressure.

Furthermore, CoQ10 is known to boost energy levels, act as an antioxidant, promote anti-aging effects, enhance cognitive function, and support immune function. Some studies have shown significant improvements in exercise performance, sperm motility, and even migraine relief with CoQ10 supplementation.

With such a wide range of potential benefits, it’s clear that CoQ10 supplementation could be a valuable addition to your daily health regimen.

Timing Your CoQ10 Intake

Timing Your CoQ10 Intake
The ideal timing for CoQ10 intake largely depends on individual preferences. CoQ10 can be taken in the morning or at night, depending on your personal needs and lifestyle.

One key factor to consider is that CoQ10 is generally more effective when taken with a high-fat meal, as this enhances its absorption and bioavailability.

Best time to take coq10: Morning or night?

While CoQ10 can be taken at any time, choosing to take it in the morning or evening may hinge on personal preference and potential side effects. Taking CoQ10 in the morning may offer benefits such as enhanced cardiovascular health, regulation of blood pressure, and improved exercise and physical performance afterwards. However, potential interactions with medications and limited effectiveness for certain conditions can be drawbacks, so it’s important to consult a healthcare professional before taking CoQ10.

On the other hand, taking CoQ10 in the evening may lead to improved sleep quality and decreased fatigue. Nevertheless, some individuals may experience difficulty sleeping or medication interactions when taking CoQ10 at night. As always, it’s best to consult with a healthcare professional before starting any new supplement to ensure the best results for your unique situation.

With or without food?

Being a fat-soluble compound, CoQ10 should ideally be taken with a meal to optimize absorption and reduce gastrointestinal discomfort. In fact, clinical studies have shown that ingesting CoQ10 with a high-fat meal can significantly increase the body’s absorption of the supplement. Examples of high-fat meals include:
  • Avocados
  • Nuts
  • Seeds
  • Olive oil
  • Fatty fish
  • Full-fat dairy products
Just remember to store your CoQ10 supplement in a cool, dark environment, as it is sensitive to heat and light.

CoQ10 Dosage Recommendations

CoQ10 Dosage Recommendations
The required CoQ10 dosage varies depending on an individual’s health status and personal circumstances. Different doses of CoQ10 are recommended accordingly. A typical daily dose for CoQ10 ranges from 100 to 300 milligrams per day, with some clinical trials using higher doses of up to 1,200 milligrams.

Nevertheless, consulting a healthcare professional for tailored recommendations is crucial to ensure the dosage taken aligns with your specific needs.

Standard dosages

Your goals will determine the amount of CoQ10 supplements required. The standard dosages typically range from 60 to 500 milligrams daily. The maximum recommended dose is 1,200 milligrams a day. For individuals with heart failure or angina, a suggested dosage of 60-300mg of CoQ10 per day may be beneficial.

Keep in mind that factors like age, health conditions, and dietary habits can affect the efficacy of CoQ10. Consulting a healthcare professional can provide tailored advice based on your specific health needs and medications, ensuring you receive the best results from your CoQ10 supplementation.

Dosage adjustments for specific health concerns

In some cases, dosage adjustments may be necessary for specific health concerns. For example, adults taking statins may require between 100-400mg of CoQ10 per day to help alleviate muscle pain. Other health concerns that may necessitate dosage adjustments include:
  • Heart disease
  • Migraines
  • Aging
  • Diabetes
  • Infertility
  • Exercise performance
If you’re contemplating CoQ10 supplementation for a particular health concern, consulting a healthcare professional for personalized guidance is crucial. They can help determine the most appropriate dosage based on your unique needs and ensure there are no potential interactions with natural medicines or precautions to consider.

CoQ10 Interactions and Precautions

CoQ10 Interactions and Precautions
CoQ10 can interact with certain medications and may not be suitable for everyone. Some potential interactions to be aware of include blood-thinning medications, chemotherapy drugs, and certain antidepressants.

Before starting CoQ10 supplementation, ensure you consult a healthcare professional to identify any potential interactions or precautions pertaining to your individual situation.

Medication interactions

CoQ10 may interact with medications such as statins, blood thinners, and blood pressure medications. For example, CoQ10 has been shown to help mitigate muscle-related adverse effects in individuals taking statins, but it’s important to consult a healthcare provider before starting supplementation to avoid potential interactions.

Should you be taking blood thinners, chemotherapy drugs, or certain antidepressants, discussing potential interactions with your healthcare provider prior to starting CoQ10 is crucial. They can help determine the most appropriate dosage and form of CoQ10 for your specific needs and ensure there are no potential interactions or precautions to consider.

Safety considerations

CoQ10 is generally well tolerated and considered safe for most individuals when taken in accordance with recommended doses. However, safety data is lacking for pregnant or breastfeeding women, so it’s important to consult a healthcare professional before taking CoQ10 if you are in this category. Additionally, individuals with certain medical conditions should exercise caution and consult a healthcare professional before starting supplementation.

Some potential side effects of CoQ10 supplementation include:
  • Nausea
  • Diarrhea
  • Heartburn
  • Headaches
If you experience any of these symptoms, it may be necessary to reduce the dosage or discontinue use.

Before starting any dietary supplement or regimen, including CoQ10, it’s always advisable to consult a healthcare professional to ensure optimal results for your unique situation.

Natural Sources of CoQ10

CoQ10 can be found naturally in various food sources, such as organ meats (e.g. liver and kidney), fatty fish (e.g. salmon and trout), nuts and seeds, spinach, broccoli, and whole grains.

Nevertheless, as we age or confront specific health conditions, supplementation may be required to maintain optimal levels of CoQ10.

Top food sources

Top food sources of CoQ10 include oily fish, organ meat, and whole grains. Some other examples are broccoli, nuts, seeds, spinach, and vegetables.

Keep in mind that solely relying on dietary intake may not be enough to maintain optimal levels of CoQ10, especially as we age or deal with particular health conditions.

Balancing dietary intake and supplementation

Balancing dietary intake with supplementation can help ensure adequate CoQ10 levels, especially for those with declining production due to age or health conditions. While natural food sources can provide some CoQ10, supplementation may be beneficial for those with certain health conditions or those who have lower levels of CoQ10.

Consulting a healthcare professional is crucial in determining the appropriate balance between diet and dietary supplements for your specific needs.

Forms of CoQ10 Supplements

Forms of CoQ10 Supplements
There are two main forms of CoQ10 supplements: ubiquinol and ubiquinone, each with varying bioavailability and effectiveness.

Comprehending the distinctions between these two forms can guide you in selecting the CoQ10 supplement that best suits your individual needs and preferences.

Ubiquinol vs. ubiquinone

Ubiquinol is the more bioavailable form of CoQ10, meaning it is more easily absorbed by the body and generally more effective than ubiquinone, the oxidized form. As the active form of CoQ10, ubiquinol is more stable and less prone to degradation in the body, providing superior absorption and efficacy.

Ubiquinone, on the other hand, requires conversion in the body before it can be utilized for energy production and antioxidant activity. Although ubiquinone is still beneficial, its lower bioavailability may make it less effective for certain individuals or health conditions.

Choosing the right form for you

The selection of the most suitable form of CoQ10 hinges on your personal needs, preferences, and health conditions. While ubiquinol is generally more effective and bioavailable, it can also be more expensive due to the complexity of its production.

Ubiquinone, although less bioavailable, may be a more affordable option for those with dietary restrictions or those who prefer a less potent form of CoQ10.

Ultimately, consulting a healthcare professional and referring to resources like the National Cancer Institute can help guide you to the best choice based on your unique situation.


In conclusion, CoQ10 is a powerful antioxidant that plays a vital role in energy production and offers numerous health benefits. To optimize its potential, it’s important to consider factors such as the best time to take CoQ10, the appropriate dosage, potential interactions and precautions, and the right form of supplement for your individual needs. By taking these factors into account and consulting with a healthcare professional, you can unlock the full potential of CoQ10 and support your journey to optimal health and well-being.

Frequently Asked Questions

What vitamins should I not take with CoQ10?

Be aware that it’s best to avoid taking beta-sitosterol, a cholesterol-lowering supplement, with fat-soluble vitamins like vitamin D and CoQ10.

Taking them together may reduce their effectiveness.

Is there any downside to taking CoQ10?

Taking CoQ10 may cause mild side effects such as digestive upset, loss of appetite, nausea, vomiting and insomnia.

It may also interact with certain medications and can lower blood pressure in some people, so it’s best to speak to your doctor first.

Can I take CoQ10 with other vitamins?

It is generally advised to avoid taking CoQ10 with other herbal/health supplements that can also lower your blood sugar or pressure. Therefore, it is best to speak with a healthcare provider before taking CoQ10 with other vitamins.

Does CoQ10 help you sleep?

CoQ10 may affect your sleep in different ways. While some studies have found CoQ10 to improve sleep quality and duration, there have been reported cases of insomnia and fatigue after taking the supplement.

It is recommended to take CoQ10 in the morning or afternoon and be aware of potential interactions with medications.

What is the best time to take CoQ10 for optimal health benefits?

For optimal health benefits, taking CoQ10 in the morning or at night with a high-fat meal is recommended.

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Michael Gonzales

Michael has a diverse set of skills and passions, with a full-time career as an airline pilot and a dedicated focus on health and fitness consulting. He understands the importance of balancing a busy lifestyle with maintaining a healthy mind and body, and is committed to helping others achieve the same success. Michael's expertise in health and fitness is not just limited to physical training, but also extends to nutrition, stress management, and overall wellbeing. He takes a holistic approach to health and fitness, helping clients to achieve their goals in a sustainable and fulfilling way. With a strong desire to inspire and motivate others, Michael is always ready to share his time and knowledge with those who seek his guidance. Whether in the air or on the ground, Michael is dedicated to helping others live their best lives.

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