Coenzyme Q10 and Migraines: Exploring the Connection

by Michael Gonzales | April 13, 2023

Coenzyme Q10 and Migraines Exploring the Connection

Coenzyme Q10 and migraines have been a subject of interest in recent years, as studies have emerged suggesting a potential link between this essential nutrient and migraine relief. In this blog post, we will explore the relationship between Coenzyme Q10 and migraines, discussing how this powerful antioxidant may help reduce the frequency and intensity of these debilitating headaches, as well as providing insight into other natural remedies and lifestyle adjustments that can complement a comprehensive migraine management plan. For a quick reference, we recommend reading Coenzyme Q10 for Energy, Coq10 and weight loss and Coenyme Q10 for Cancer Treatment articles.

What is Coenzyme Q10 and How Does it Work?

What is Coenzyme Q10 and How Does it Work?
Coenzyme Q10, also known as CoQ10 or ubiquinone, is a naturally occurring antioxidant found in the mitochondria of cells. This essential nutrient plays a vital role in cellular energy production, as it helps convert food into energy in the form of adenosine triphosphate (ATP). In addition, CoQ10 has been shown to have a number of health benefits, including supporting heart health, reducing oxidative stress, improving overall cellular function, and potentially slowing down the aging process.

The Role of CoQ10 in Migraine Prevention

The potential connection between Coenzyme Q10 and migraines comes from the antioxidant's role in maintaining healthy mitochondrial function. Migraines are believed to be partially caused by abnormal mitochondrial function, leading to inflammation and impaired cellular energy production. CoQ10's ability to support healthy mitochondrial function may help reduce the occurrence and severity of migraines by promoting better energy production, reducing oxidative stress, and improving cellular resilience.

Studies on Coenzyme Q10 and Migraines

Studies on Coenzyme Q10 and Migraines
Research on the relationship between Coenzyme Q10 and migraines has produced some promising results. In a randomized, double-blind, placebo-controlled trial, participants who took 100 mg of CoQ10 three times daily experienced a significant reduction in the frequency of migraines compared to those who took a placebo. This study showed a 50% reduction in the number of days with migraines for those taking CoQ10.

Other studies have also supported these findings, suggesting that CoQ10 supplementation may be a viable option for migraine prevention. A systematic review and meta-analysis of randomized controlled trials found that CoQ10 supplementation led to a significant decrease in the frequency and duration of migraines compared to placebo.

Dosage and Safety Considerations

When considering CoQ10 supplementation for migraines, it's essential to consult with a healthcare professional to determine the appropriate dosage. Typically, the recommended dosage for migraine prevention ranges from 100 to 300 mg per day, divided into two or three doses. CoQ10 is available in two forms – ubiquinone and ubiquinol – with ubiquinol being the more bioavailable and easily absorbed version.

CoQ10 is generally considered safe, with few reported side effects. Some individuals may experience mild side effects, such as gastrointestinal discomfort, nausea, or mild insomnia. If you experience any persistent or severe side effects, consult your healthcare provider. It's also essential to discuss any potential interactions with medications or pre-existing health conditions with a healthcare provider before starting supplementation.

Alternative Natural Supplements for Migraine Relief?

In addition to Coenzyme Q10, there are other natural supplements that have shown promise in alleviating migraines. Some of the most widely studied and recommended natural remedies for migraine prevention include:

Magnesium: This essential mineral plays a role in nerve function, muscle relaxation, and blood vessel dilation. Low magnesium levels have been linked to migraines, and supplementation has shown to be effective in reducing migraine frequency in some individuals.

Riboflavin (Vitamin B2): This water-soluble vitamin is essential for energy production and cellular function. Studies have shown that high doses of riboflavin can help reduce the frequency and severity of migraines in some people.

Butterbur: Derived from the butterbur plant, this herbal supplement has been used traditionally for headache relief. Some studies have demonstrated its effectiveness in reducing the frequency of migraines.

Feverfew: Another herbal remedy, feverfew has been used for centuries to treat headaches and migraines. Research has shown that it may help prevent migraines by reducing inflammation and preventing blood vessel constriction.

Developing a Comprehensive Migraine Management Plan

While Coenzyme Q10 and other supplements may help reduce the frequency and intensity of migraines, it's important to remember that they are just one part of a comprehensive migraine management plan. Lifestyle factors, such as maintaining a regular sleep schedule, managing stress, and avoiding migraine triggers, are also crucial components in preventing migraines. Some additional strategies to consider include:

Keep a migraine diary: Tracking your migraine episodes and potential triggers can help you identify patterns and make changes to reduce the likelihood of migraines.

Stay hydrated: Dehydration can be a trigger for migraines, so make sure to drink plenty of water throughout the day.

Eat regular, balanced meals: Skipping meals or eating irregularly can lead to blood sugar fluctuations, which may trigger migraines.

Exercise regularly: Moderate exercise has been shown to reduce the frequency and severity of migraines, possibly by improving blood flow and reducing stress.

Practice relaxation techniques: Stress is a common migraine trigger, so incorporating relaxation techniques, such as deep breathing, meditation, or yoga, can help manage stress levels and reduce the risk of migraines.


In conclusion, Coenzyme Q10 and migraines appear to have a connection, with studies showing that CoQ10 supplementation can help reduce the frequency and severity of these debilitating headaches. Alongside other natural supplements and lifestyle adjustments, CoQ10 may play a valuable role in a comprehensive migraine management plan. By taking a multifaceted approach to migraine prevention, individuals suffering from migraines may find relief and an improved quality of life.

Frequently Asked Questions

How long does it take for CoQ10 to help with migraines?

It may take several weeks to months of consistent supplementation before noticing a significant reduction in migraine frequency and intensity. Individual results may vary, and it's essential to be patient and give your body time to adjust to the supplementation.

Can I take Coenzyme Q10 with other migraine medications?

CoQ10 is generally considered safe to take alongside other medications, but it's essential to consult with a healthcare professional to discuss potential interactions. Always inform your healthcare provider of any supplements you're taking to ensure safe and effective treatment.

Are there any side effects of taking Coenzyme Q10?

CoQ10 is generally well-tolerated, with few reported side effects. Some individuals may experience mild side effects, such as gastrointestinal discomfort, nausea, or mild insomnia. If you experience any persistent or severe side effects, consult your healthcare provider.

What are some food sources of Coenzyme Q10?

CoQ10 can be found in a variety of foods, including organ meats (such as liver and kidney), beef, pork, oily fish (such as salmon and mackerel), nuts, and whole grains. However, the amounts found in food are typically lower than what is provided in supplements, and it may be challenging to obtain sufficient amounts through diet alone.

Can Coenzyme Q10 help with other types of headaches?

While CoQ10 has shown promise in reducing the frequency and intensity of migraines, there is limited research on its effectiveness for other types of headaches. If you're considering CoQ10 for non-migraine headaches, consult with a healthcare professional to discuss its potential benefits and risks. Incorporating other natural remedies and lifestyle changes, as discussed in this blog post, may also be beneficial for managing different types of headaches.

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Michael Gonzales

Michael has a diverse set of skills and passions, with a full-time career as an airline pilot and a dedicated focus on health and fitness consulting. He understands the importance of balancing a busy lifestyle with maintaining a healthy mind and body, and is committed to helping others achieve the same success. Michael's expertise in health and fitness is not just limited to physical training, but also extends to nutrition, stress management, and overall wellbeing. He takes a holistic approach to health and fitness, helping clients to achieve their goals in a sustainable and fulfilling way. With a strong desire to inspire and motivate others, Michael is always ready to share his time and knowledge with those who seek his guidance. Whether in the air or on the ground, Michael is dedicated to helping others live their best lives.

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