If you've dabbled in the world of supplements, you've probably stumbled upon Coenzyme Q10, or as many know it, CoQ10. This naturally occurring coenzyme has made waves in the supplement world. But, life's never a straight path, is it? Especially when we talk about mixing and matching supplements. The golden query here: "What vitamins should I not take with CoQ10?" Don't fret; we're diving deep to unravel this mystery for you.
No common vitamin is known to be unsafe to take with CoQ10. Major references, including the NIH's National Center for Complementary and Integrative Health, don't list harmful vitamin interactions. CoQ10's notable interactions are with medicines: it may interact with the blood thinner warfarin and with insulin. If you take either, talk to your healthcare professional before starting CoQ10.
The Power and Popularity of CoQ10

CoQ10 isn’t just another pill in your medicine cabinet. Produced naturally by our bodies, this coenzyme's main gig is all about energy. It’s responsible for energy production within our cells. But that's not all; it's also renowned for its antioxidant properties, battling those pesky free radicals that cause cellular damage. But remember, as with any supplement, it's worth knowing how CoQ10 fits with everything else you take.
The Dance of Antioxidants
Are There Vitamins to Veer Away from When Taking CoQ10?

What vitamins should I not take with CoQ10?
Potential Pitfalls
Best Time to Take CoQ10

How Long Before You Notice Anything?
Conclusion
What the Research Says About CoQ10 and Vitamins
CoQ10 is a fat-soluble compound your body makes itself, which is why it isn't classed as a vitamin. Rather than competing with other antioxidants, it works alongside them. The Linus Pauling Institute describes how the active form of CoQ10 can help regenerate vitamin E and vitamin C after they neutralize free radicals. Vitamin E and CoQ10 are the main fat-soluble antioxidants in your cell membranes.
B vitamins play a part too: your body uses pantothenic acid (vitamin B5) and vitamin B6 in the steps that build CoQ10. None of this points to a vitamin you need to avoid. As with any combination of supplements, though, it's wise to check your total doses with your healthcare professional.
Medicines to Ask About Before Taking CoQ10
The interactions that matter involve medications, not vitamins:
- Warfarin. CoQ10 has been reported to reduce warfarin's effect in a few cases. The Linus Pauling Institute advises that anyone on warfarin should not start CoQ10 without first talking to the healthcare professional who manages their warfarin, who may want to check clotting tests more often. Never change your medication on your own.
- Insulin. NCCIH notes that CoQ10 may interact with insulin.
- Some cancer treatments. NCCIH says CoQ10 may not be compatible with some types of cancer treatment.
- Statins and other medicines. Statins can lower the amount of CoQ10 in your blood, and the National Cancer Institute notes that some drugs used to lower cholesterol, blood pressure or blood sugar may decrease CoQ10's effects.
CoQ10 Side Effects to Know About
No serious side effects of CoQ10 have been reported, according to NCCIH. Some people notice mild insomnia or digestive upset. The Linus Pauling Institute says stomach symptoms such as nausea, diarrhea and heartburn are more likely at 200 mg a day or more, and that splitting daily amounts above 100 mg into two or three doses may help. Reliable data during breastfeeding are lacking, so if you are pregnant or breastfeeding, talk to your healthcare professional first.
How to Take CoQ10 Alongside Other Supplements
Because CoQ10 is fat-soluble, it is best absorbed with a meal that contains some fat. You can take it with your other supplements at that meal. For more on timing, see our guide to the best time to take CoQ10.
Frequently Asked Questions
How does CoQ10 benefit the body?
Can you take CoQ10 on an empty stomach?
How long does it take to notice the effects of CoQ10?
Is CoQ10 safe for everyone to take?
Can CoQ10 and Vitamin C be taken together?
Can you take CoQ10 with vitamin E?
There is no known harmful interaction. Vitamin E and CoQ10 are the main fat-soluble antioxidants in cell membranes, and the Linus Pauling Institute describes CoQ10 helping to regenerate vitamin E. If you take high doses of either, check with your healthcare professional.
Can you take CoQ10 with a multivitamin or B vitamins?
NCCIH and the Linus Pauling Institute don't list any interaction between CoQ10 and multivitamins or B vitamins. In fact, your body uses vitamin B5 and vitamin B6 to make CoQ10. Taking them together with a meal is a common approach.
Can I take CoQ10 if I take warfarin?
CoQ10 may reduce warfarin's effect. Don't start CoQ10, and don't change your warfarin, without talking to the healthcare professional who manages your warfarin first.
What are the side effects of CoQ10?
NCCIH reports no serious side effects. Mild insomnia or digestive upset can occur, and stomach symptoms are more common at 200 mg a day or more.
